The research evidence for schizophrenia as a neurodevelopmental disorder

Is schizophrenia a neurodevelopmental disorder?

Supportive neurodevelopmental evidence for ADHD as a developmental disorder.

A baby is dependent on its primary caregiver (hereafter referred to as 'mother') for its emotional regulation. The development of emotional self-regulation is dependent on the growth and myelinisation of connections between cortical (control) and limbic (emotion) structures in the infant brain. The subcortical sympathetic limbic system is dominant from birth, and it is only at 14-18 months of a...

Schizophrenia is (not simply) a neurodevelopmental disorder.

Schizophrenia affects almost 1% of the population at some point in their life. It occurs in all geographic areas in which studies have been done, although the outcome appears to be better in developing countries. In this editorial we will discuss the evidence, from epidemiological, genetic and neuroimaging studies, that suggests that schizophrenia is in part a neurodevelopmental disorder. Howev...

Epilepsy as a Neurodevelopmental Disorder

Epilepsy is characterized by spontaneous recurrent seizures and comprises a diverse group of syndromes with different etiologies. Epileptogenesis refers to the process whereby the brain becomes epileptic and can be related to several factors, such as acquired structural brain lesions, inborn brain malformations, alterations in neuronal signaling, and defects in maturation and plasticity of neur...

Evidence for schizophrenia as a disorder of neuroplasticity.

Neuroplasticity is the ability of the brain to change and adapt in response to changes in its input, by an alteration in the number of neurons or glia via cell division or apoptosis, by formation of new circuits, by strengthening or weakening specific synapses, by changing the number of dendritic spines, and/or by other mechanisms (1–3). In this issue, Li et al. (4) provide new evidence for alt...